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Comparison of epidural sufentanil plus clonidine with sufentanil alone for postoperative pain relief
Author(s) -
VERCAUTEREN M.,
LAUWERS E.,
MEERT T.,
HERT S. DE,
ADRIAENSEN H.
Publication year - 1990
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1990.tb14824.x
Subject(s) - sufentanil , medicine , anesthesia , clonidine , epidural administration , blood pressure , abdominal surgery , pain relief , surgery , morphine
Summary Sufentanil 25 μg plus clonidine 1 μg/kg administered epidurally was compared with epidural sufentanil 50 μg alone in a double‐blind fashion for pain relief in 40 patients after abdominal surgery. The duration of complete pain relief was significantly longer in those who received the mixture. Oxygen saturation was reduced 10 and 20 minutes after sufentanil alone, but remained stable after sufentanil and clonidine. There were significant decreases in arterial blood pressure in the latter group that were maximum between 20 and 120 minutes after administration.