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Pressor responses to tracbeal intubation after sublingual captopril A pilot study
Author(s) -
McCarthy G. J.,
Hainsworth M.,
Lindsay K.,
Wright J. M.,
Brown T. A.
Publication year - 1990
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1990.tb14697.x
Subject(s) - medicine , captopril , intubation , anesthesia , sublingual administration , blood pressure
Summary The effect of sublingual captopril on the pressor response to intubation was studied in 40 patients. Captopril was used in one of two doses (12.5 mg and 25 mg) 25 minutes before tracheal intubation. Both doses were associated with a significant reduction in the pressor response to intubation (p < 0.05) compared to placebo, but no significant difference existed between the two doses. Neither dose controlled changes in heart rate at intubation. Untoward hypotension occurred in the treatment groups. Caution is advised in the peri‐operative use of angiotensin‐converting enzyme inhibitors.