Premium
Flumazenil in ketamine and midazolam anaesthesia
Author(s) -
RESTALL J.,
JOHNSTON I. G.,
ROBINSON D. N.
Publication year - 1990
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1990.tb14623.x
Subject(s) - flumazenil , medicine , midazolam , ketamine , anesthesia , placebo , incidence (geometry) , benzodiazepine , sedation , physics , receptor , alternative medicine , pathology , optics
Summary A double‐blind, parallel group study using flumazenil and placebo was carried out to determine whether patients who received flumazenil would awake more quickly and whether this drug would reverse the protection conferred by midazolam on the psychic sequelae of ketamine. Fifty female patients were studied. The results showed that there was a significant reduction in awakening time (p = 0.02) and a very significant increase (p = 0.001) in the incidence of dreams in the flumazenil group.