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Gelling of urea‐linked gelatin with fresh frozen plasma
Author(s) -
MURRAY F.,
HUTTON P.
Publication year - 1989
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1989.tb11335.x
Subject(s) - gelatin , urea , fresh frozen plasma , chromatography , medicine , albumin , coagulation , biochemistry , chemistry , platelet
Summary Urea‐linked gelatin and succinylated gelatin were mixed with fresh frozen plasma and human albumin solutions in vitro, in varying concentrations and at different temperatures. Gelling was only seen in those mixtures that contained fresh frozen plasma and urea‐linked gelatin. It occurred at both room temperature and 37°C when the mixture contained more than 40% by volume of urea‐linked gelatin. Further tests confirmed that this was the result of calcium ions in the urea‐linked gelatin allowing coagulation to occur in the fresh frozen plasma.