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The effect of acutely administered phenytoin on vecuronium‐induced neuromuscular blockade
Author(s) -
GRAY H. St. J.,
SLATER R.M.,
POLLARD B.J.
Publication year - 1989
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1989.tb11331.x
Subject(s) - neuromuscular blockade , medicine , phenytoin , anesthesia , blockade , vecuronium bromide , saline , neuromuscular transmission , pharmacology , epilepsy , receptor , psychiatry
Summary Phenytoin was administered intravenously in a dose of 10 mg/kg to a group of patients in whom steady state neuromuscular blockade had been established with an infusion of vecuronium. A control group of patients were given 0.9% saline instead of phenytoin. Administration of phenytoin produced significant augmentation of neuromuscular blockade (p < 0.001). The possible mechanism of this effect is discussed.