Premium
Effect of intravenous cimetidine on lignocaine disposition during extradural Caesarean section
Author(s) -
FLYNN R. J.,
MOORE J.,
COLLIER P. S.,
HOWARD P. J.
Publication year - 1989
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1989.tb09259.x
Subject(s) - cimetidine , medicine , anesthesia , intravenous bolus , disposition , caesarean section , bolus (digestion) , antagonist , elective caesarean section , pregnancy , surgery , pharmacology , receptor , psychology , social psychology , biology , genetics
Summary We studied whether an intravenous bolus of cimetidine altered the disposition of extradurally administered lignocaine in the parturient. Mothers who requested extradural analgesia for elective Caesarean section were randomly pretreated with either cimetidine 200 mg intravenously (n = 5) or no H 2 ‐receptor antagonist (n = 5). No difference was found between peak plasma lignocaine levels or area under the plasma concentration/time curve between the two groups after administration of 6 mg/kg lignocaine 2% with adrenaline 1:200 000. There was no evidence for an effect of a single intravenous dose of cimetidine on lignocaine disposition in the obstetric patient. In addition, the extradural administration of 6 mg/kg lignocaine produces plasma levels well below toxic levels.