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Dose‐response studies of atracurium, vecuronium and pancuronium in the elderly
Author(s) -
Bell P. F.,
Mirakhur R. K.,
Clarke R. S. J.
Publication year - 1989
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1989.tb09152.x
Subject(s) - potency , medicine , anesthesia , atracurium besilate , pharmacology , neuromuscular blockade , biochemistry , chemistry , in vitro
Summary Dose‐response curves were constructed for atracurium. vecuronium and pancuronium in elderly subjects in order to assess potency of these relaxants. The results were compared to data previously obtained for adult subjects using the same method. A single‐dose method of potency determination was used in both studies. The results indicate no significant difference in the potency of these relaxants between elderly and adult subjects; the ED 95 s were 249 and 226 μg/kg for atracurium, 43.1 and 39.6 μg/kg, for vecuronium and 65.9 and 60 μg/kg for pancuronium respectively in the elderly and the adults.