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A comparison between propofol and ketamine for anaesthesia in the elderly. Haemodynamic effects during induction and maintenance
Author(s) -
Maneglia R.,
Cousin M. T.
Publication year - 1988
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1988.tb09090.x
Subject(s) - medicine , propofol , anesthesia , hemodynamics , ketamine , pulmonary wedge pressure , bolus (digestion) , cardiac output , blood pressure , vascular resistance , heart rate , mean arterial pressure , surgery
Summary The haemodynamic effects of propofol and ketamine were studied in two groups of eight randomly allocated elderly patients (mean age 85.8 years) anaesthetised for hip replacement. Group 1 patients received propofol 1 mg/kg by intravenous bolus for induction and 0.1 mg/kg/minute by continuous infusion for maintenance. Group 2 patients received ketamine 1.5 mg/kg by intravenous bolus as induction dose and 50 μg/kg/minute by continuous infusion for maintenance. All patients breathed spontaneously via a facemask at FIO 2 1.0. Haemodynamic status was established before induction and at 1, 3, 5, 10 and 15 minutes after induction. Arterial pressure and cardiac output decreased slightly in group 1 but heart rate, right atrial pressure and pulmonary arterial pressure remained unchanged. Myocardial oxygen consumption showed a significant decrease of 27%. There was a significant increase in blood pressure and pulmonary capillary wedge pressure (by 97%) in group 2. Cardiac output and systemic vascular resistance remained unchanged whereas myocardial oxygen consumption showed a very significant increase of 100%.