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Effect of propofol on elevated intracranial pressure. Preliminary results
Author(s) -
Herregods L.,
Verbeke J.,
Roily G.,
Colardyn F.
Publication year - 1988
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1988.tb09089.x
Subject(s) - medicine , propofol , cerebral perfusion pressure , intracranial pressure , anesthesia , blood pressure , bolus (digestion) , mean arterial pressure , perfusion , mean blood pressure , hemodynamics , heart rate , cardiology , cerebral blood flow
Summary The effects of a bolus injection of propofol on mean intracranial pressure were studied in six adult, comatose patients who had severe head injuries. Propofol 2 mg/kg was given intravenously over 90 seconds when the mean intracranial pressure reached or exceeded 25 mmHg. Arterial blood gas values, heart rate and central venous pressure remained stable at all measurements. Arterial blood pressure decreased statistically significantly (p < 0.05) within one minute after propofol administration. The mean (SEM) intracranial pressure decreased statistically significantly (p < 0.05) at 30 seconds and at J and 2 minutes, from 25 (3) to 11 (4) mmHg. The cerebral perfusion pressure decreased statistically significantly from 92 (8) mmHg at all measurements (p < 0.05). The lowest value at 3 minutes was 50 (7) mmHg but in jour patients at that time the perfusion pressure was below 50 mmHg.