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Effect of propofol on cerebral blood flow and metabolism in man
Author(s) -
VANDESTEENE A.,
TREMPONT V.,
ENGELMAN E.,
DELOOF T.,
FOCROUL M.,
SCHOUTENS A.,
ROOD M.
Publication year - 1988
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1988.tb09067.x
Subject(s) - medicine , propofol , cerebral blood flow , enflurane , anesthesia , oxygen , nitrous oxide , metabolism , blood flow , oxygen metabolism , halothane , chemistry , organic chemistry
Summary Cerebral blood flow, cerebral oxygen consumption, lactate and glucose metabolism were measured in 13 patients during anaesthesia with nitrous oxide, oxygen and enflurane 0.5% and after 30 minutes infusion of propofol. The mean blood concentration of propofol was 4.06 μg/ml. Cerebral blood flow decreased by 27.6% and cerebral vascular resistance by 51%. There were no changes in lactate and glucose metabolism. Cerebral oxygen consumption decreased by 18.25%. Changes in the electroencephalograph were related to the blood levels of propofol .