Premium
Pharmacokinetics of propofol administered by continuous infusion in patients with cirrhosis
Author(s) -
SERVIN F.,
DESMONTS J. M.,
FARINOTTI R.,
HABERER J. P.,
WTNCKLER C.
Publication year - 1988
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1988.tb09063.x
Subject(s) - medicine , propofol , cirrhosis , volume of distribution , pharmacokinetics , anesthesia , plasma clearance , distribution (mathematics) , blood volume , gastroenterology , mathematical analysis , mathematics
Summary Anaesthesia was provided by an infusion of propofol in six healthy patients and six patients with hepatic cirrhosis. There were no significant differences between the groups with regard to the central compartment volume, distribution volume at steady state, total apparent distribution volume, total body clearance or elimination half‐life, although the values were always greater in the cirrhotic patients. Recovery times were significantly longer in the patients with cirrhosis.