Premium
Acetylcholinesterase ‐ a specific marker for cerebrospinal fluid
Author(s) -
VANNER R. G.
Publication year - 1988
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1988.tb08978.x
Subject(s) - cerebrospinal fluid , medicine , acetylcholinesterase , serial dilution , lumbar puncture , cholinesterase , pathology , enzyme , anesthesia , pharmacology , biochemistry , chemistry , alternative medicine
Summary An oedematous pre‐eclamptic patient received lumbar epidural analgesia during labour. Clear fluid leaked from the skin puncture site for 4 days. The fluid was analysed using protein electrophoresis for cholinesterase enzymes and was found not to contain the cerebrospinal fluid specific form of the enzyme, acetylcholinesterase. The sensitivity of this test was explored using serial dilutions of cerebrospinal fluid. It is now possible to say that the leaking fluid did not contain cerebrospinal fluid.