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Benzodiazepine intoxication treated with flumazenil (Anexate, RO 15–1788)
Author(s) -
KNUDSEN L.,
LONKA L.,
SØRENSEN B. H.,
KIRKEGAARD L.,
JENSEN O. V.,
JENSEN S.
Publication year - 1988
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1988.tb08971.x
Subject(s) - flumazenil , medicine , benzodiazepine , anesthesia , pharmacology , receptor
Summary The efficacy and safety of flumazenil were assessed in comparison to placebo in a double‐blind randomised study of 31 adults intoxicated with benzodiazepines. The criteria of efficacy were the degree of sedation, and orientation in time and space. Patients who received flumazenil awoke within minutes but central depression returned partly one hour later, which reflects the short elimination half‐life of the drug. Side effects were few and the results indicate that flumazenil is effective in the primary management of benzodiazepine overdose and in states where benzodiazepines have been taken with other drugs.