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Suxamethonium induced myalgia and the effect of pre‐operative administration of oral aspirin
Author(s) -
McLOUGHLIN C.,
NESBITT G. A.,
HOWE J. P.
Publication year - 1988
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1988.tb06689.x
Subject(s) - medicine , myalgia , anesthesia , aspirin , oral administration , incidence (geometry) , surgery , optics , physics
Summary Eighty‐four fit, unpremedicated patients who presented for routine surgery and received a standard anaesthetic technique were allocated randomly to three equal groups. Group 1 received tubocurarine 0.05 mg/kg before induction of anaesthesia. Group 2 received soluble aspirin 600 mg orally one hour before surgery, while Group 3 received no pretreatment. Aspirin prophylaxis produced a significant reduction in the incidence of subsequent suxamethonium‐induced myalgia and the improvement was similar to that achieved with tubocurarine pretreatment. Pre‐operative oral administration of aspirin effectively reduces muscle pains and avoids many of the complications associated with pretreatment with non‐depolarising agents.