Premium
Absorption of buccal morphine
Author(s) -
FISHER A. P.,
FUNG C.,
HANNA M.
Publication year - 1988
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1988.tb06684.x
Subject(s) - morphine , medicine , buccal administration , absorption (acoustics) , enteral administration , anesthesia , buccal mucosa , chromatography , pharmacology , parenteral nutrition , dentistry , chemistry , physics , oral cavity , acoustics
Summary The absorption of buccal morphine was compared with that of slow‐release morphine sulphate in human volunteers. Morphine concentration was assayed by high pressure liquid chromatography in serum samples obtained at intervals up to 8 hours after administration of morphine 20 mg. Similar mean maximum concentrations were obtained by either route, hut the mean time to maximum concentration was longer after buccal than after enteral administration.