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Anaesthesia and angiotensin‐converting enzyme inhibitors
Author(s) -
YATES A. P.,
HUNTER D. N.
Publication year - 1988
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1988.tb05655.x
Subject(s) - enalapril , medicine , intubation , stimulation , renin–angiotensin system , anesthesia , angiotensin converting enzyme , hemodynamics , heart rate , general anaesthesia , haemodynamic response , tracheal intubation , angiotensin ii , blood pressure , cardiology
Summary The effect of enalapril pretreatment on the haemodynamic response to tracheal intubation and surgical stimulation has been studied in 22 patients. Enalapril 5 mg given 4 hours before operation was associated with a significant reduction in the pressor response associated with intubation (p < 0.05) and surgical stimulation (p < 0.005) compared with control. Heart rate changes were similar in the two groups. The role of the renin‐angiotensin system in relation to the pressor response to sympathetic stimulation is discussed and it is concluded that angiotensin‐converting enzyme inhibitors may help improve peri‐operative cardiovascular stabiity.