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Plasma bupivacaine concentrations during caudal analgesia and ilioinguinal‐iliohypogastric nerve block in children
Author(s) -
STOW P. J.,
SCOTT A.,
PHILLIPS A.,
WHITE J. B.
Publication year - 1988
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1988.tb04150.x
Subject(s) - bupivacaine , medicine , anesthesia , analgesic , nerve block , plasma concentration , microgram , surgery , biochemistry , chemistry , in vitro
Summary Plasma bupivacaine concentrations were measured in 27 children aged 3 ‐7 years who received one of two analgesic regimens for herniotomy or orchidopexy. Analgesia was provided either by caudal epidural bupivacaine 0.2% 2 mg/kg (n = 14) or by ilioinguinal‐iliohypogastric nerve block with bupivacaine 0.5% 1.25 mg/kg (n = 13). Mean (SD) peak venous bupivacaine concentrations were 0.57 (0.17) μg/ml and 0.79 (0.38) μg/ml respectively. Time to peak plasma concentrations were 29.6 (7.9) and 22.3 (10.9) minutes respectively. These concentrations are well below the potentially toxic level of 4.0 μg/ml, but suggest that uptake of bupivacaine is more rapid after ilioinguinal iliohypogastric nerve block than during caudal analgesia.