Premium
Anti‐adrenal action of a subanaesthetic dose of etomidate
Author(s) -
DIAGO M. C.,
AMADO J. A.,
OTERO M.,
LOPEZCORDOVILLA J. J.
Publication year - 1988
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1988.tb04148.x
Subject(s) - etomidate , medicine , aldosterone , sedation , corticosteroid , anesthesia , bolus (digestion) , adrenocorticotropic hormone , intravenous bolus , hormone , endocrinology , pharmacology , propofol
Summary The effects of subanaesthetic doses of etomidate on corticosteroid synthesis have been studied in vivo. In the group of patients who received etomidate (n = 10), cortisol and aldosterone responses to adrenocorticotrophic hormone were blunted, while 11 de‐oxycortisol response was increased, as compared to a control group (n = 10). These results suggest that a single bolus of 0.04 mg/kg etomidate, which produces sedation, without loss of consciousness, is able to block adrenal 11 hydroxylase.