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The effects of vecuronium on intra‐ocular pressure
Author(s) -
MIRAKHUR R. K.,
SHEPHERD W. F. I.,
LAVERY G. G.,
ELLIOTT P.
Publication year - 1987
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1987.tb05364.x
Subject(s) - rapid sequence induction , medicine , anesthesia , intubation , tracheal intubation , vecuronium bromide , sequence (biology) , chemistry , biochemistry
Summary The effects of vecuronium on intra‐ocular pressure were investigated in doses of O.1 mg/kg during steady state anaesthesia (n = 5), 0.1 mg/kg as part of a normal sequence induction preceded by thiopentone (n = 10), and 0.15 mg/kg as part of a rapid sequence induction with vecuronium administered prior to thiopentone (n = 10). Administration of vecuronium during steady state anaesthesia was associated with a significant decrease. Vecuronium produced a small reduction in pressure during a normal sequence induction, following a significant reduction after thiopentone. Tracheal intubation during normal sequence and rapid sequence inductions produced increases in pressure above the pre‐intubation value (significantly so in the case of normal sequence induction); however, the intra‐ocular pressure always remained helow the pre‐induction value, which suggests that vecuronium 0.15 mg/kg is a suitable relaxant as part of a rapid sequence induction technique where the use of suxamethonium is contraindicated.