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Fatal disseminated intravascular coagulation following a monoamine oxidase inhibitor/tricyclic interaction
Author(s) -
TACKLEY R. M.,
TREGASKIS B.
Publication year - 1987
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1987.tb05324.x
Subject(s) - medicine , disseminated intravascular coagulation , tranylcypromine , monoamine oxidase inhibitor , tricyclic , clomipramine , coagulation , coagulopathy , anesthesia , pharmacology , monoamine oxidase , biochemistry , chemistry , enzyme
Summary In spite of intensive therapy, an otherwise fit 34‐year‐old man died following the hyperpyrexial reaction to an interaction between tranylcypromine and clomipramine. There was no evidence of drug overdose, but severe disseminated intravascular coagulation developed which proved fatal.