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Low dose sufentanil pretreatment
Author(s) -
FURNESS G.,
DUNDEE J. W.,
MILLIGAN K. R.
Publication year - 1987
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1987.tb05271.x
Subject(s) - sufentanil , medicine , midazolam , anesthesia , methohexital , sedation , propofol
Summary The effects of pretreatment with varying doses of sufentanil on the subsequent induction of anaesthesia with thiopentone, methohexitone or midazolam were studied in 240 healthy patients. The induction dose requirements for the barbiturates were significantly reduced by sufentanil 5.0 μg (methohexitone p < 0.05. thiopentone p < 0.01). Excitatory effects following methohexitone were decreased (p < 0.01) but brief respiratory depression was increased in both cases. Midazolam onset time was reduced, as was the frequency of failed induction, after sufentanil 5.0 μg (p < 0.01).