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Analgesia from morphine and ketamine
Author(s) -
OWEN H.,
REEKIE R. M.,
CLEMENTS J. A.,
WATSON R.,
NIMMO W.S.
Publication year - 1987
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1987.tb05167.x
Subject(s) - medicine , ketamine , morphine , anesthesia , analgesic , pain relief , depression (economics) , economics , macroeconomics
Summary Ketamine 4 μg/kg/minute produced pain relief similar to that from morphine 33 μg/minute in a doubleblind study that compared analgesia from constant‐rate intravenous infusions of the two drugs in 60 patients. The analgesic efficacy of the infusions, as assessed by pain scores and the requirement for supplementary self‐administered morphine, was poor. Ventilatory depression, the most significant side effect, occurred only in patients who received morphine infusion. The low dose ketamine infusion did not provide clinically useful analgesia even though adequate plasma concentrations were achieved.