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Intranasal nitroglycerine attenuates pressor response to tracheal intubation in beta‐blocker treated hypertensive patients
Author(s) -
Grover V. K.,
Sharma S.,
Mahajan R. P.,
Singh H.
Publication year - 1987
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1987.tb04119.x
Subject(s) - medicine , laryngoscopy , anesthesia , tracheal intubation , intubation , blood pressure , heart rate , hemodynamics , mean arterial pressure , placebo , saline , nasal administration , pharmacology , alternative medicine , pathology
Summary The effect of intranasal nitroglycerine on the pressor response to laryngoscopy and tracheal intubation was studied in 40 adult hypertensive patients treated with beta‐blocking drugs. Nitroglycerine 0.75 mg, administered intranasally 30 seconds before induction of anaesthesia, was compared with a placebo solution of saline. Haemodynamic variables were measured for 10 minutes after laryngoscopy and tracheal intubation. Heart rate did not change significantly in either group. Systolic as well as mean arterial blood pressure increased significantly for the first 5 minutes in the control group, whereas patients in the nitroglycerine group showed a decrease in systolic as well as in mean arterial pressure. No patient in the nitroglycerine group showed a decrease in systolic arterial pressure greater than 20 mmHg. In conclusion, intranasal nitroglycerine ameliorates the pressor response to laryngoscopy and tracheal intubation in beta‐blocked patients.