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Propofol combined with nitrous oxide‐oxygen for induction and maintenance of anaesthesia
Author(s) -
HERREGODS L.,
ROLLY G.,
VERSICHELEN L.,
ROSSEEL M. T.
Publication year - 1987
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1987.tb03975.x
Subject(s) - nitrous oxide , medicine , propofol , anesthesia , oxygen , organic chemistry , chemistry
Summary After a bolus of 2 mg/kg, propofol was given by continuous infusion (150 μg/kg/minute for 30 minutes and then 100 μg/kg/minute) supplemented with nitrous oxide for anaesthesia during ear surgery in 12 patients. Cardiovascular changes were not significant except for a decrease in heart rate after 60 minutes. Acid‐base balance was unaffected by the amount of fatty emulsion. Cortisol levels showed a nonsignificant decrease during the prolonged administration of propofol but had recovered completely by one hour following anaesthesia. Mean blood concentrations of propofol were 10.5 μg/ml (SEM 1.2) at the onset of unconsciousness, between 3.4 and 4.5 μg/ml during continuous infusion and 2.9 μg/ml (SEM 0.3) on awakening. Patients opened their eyes 6 minutes (SEM 1) after discontinuation of the infusion, and were responsive at 7.5 minutes (SEM 0.5), which suggests that propofol infusion can be used safely for surgery of 2 hours' duration.