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Acute beta‐adrenoreceptor blockade and induced hypotension
Author(s) -
SIMPSON D. L.,
MACRAE W. R.,
WILDSMITH J. A. W.,
DALE B. A. B.
Publication year - 1987
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1987.tb03034.x
Subject(s) - medicine , blockade , beta (programming language) , anesthesia , pharmacology , receptor , computer science , programming language
Summary Thirty patients scheduled for major middle ear surgery and induced hypotension, with a trimetaphan/sodium nitroprusside infusion, were randomly allocated to receive a single oral dose of beta‐adrenoreceptor antagonist 2 hours before surgery. In group 1 ten patients received metoprolol 50 mg, in group 2 ten patients received metoprolol 25 mg and in group 3 ten patients received oxprenolol 20 mg. There were ten controls for each group. The nitroprusside infusion rate was significantly reduced in groups 1 and 3. However, there was an unacceptably high incidence of profound bradycardia after induction of anaesthesia in those patients who had received beta‐adrenoreceptor antagonists pre‐operatively and this technique is not recommended for routine use.