Vecuronium—A variable dose technique

Summary Vecuronium was administered to patients in doses of 100, 150, 200 and 250 μg/kg and the duration of action recorded by noting the time to recovery of the first twitch in a train‐of‐four to 10% of the control twitch. The recovery times ranged from a mean of 28.4 minutes (100 μg/kg) to 72.4 minutes (250 μg/kg). It is suggested that for operations of medium to long duration the use of a large initial bolus dose of vecuronium is a technique with advantages over the use of an infusion or frequent incremental doses.