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Vecuronium induced neuromuscular blockade
Author(s) -
CASSON W. R.,
JONES R. M.
Publication year - 1986
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1986.tb13217.x
Subject(s) - medicine , neuromuscular blockade , vecuronium bromide , neuromuscular junction , blockade , anesthesia , neuromuscular monitoring , neuroscience , receptor , biology
Summary The speed of onset of neuromuscular blockade was measured for increasing doses of vecuronium. Onset times were found to be shorter with larger doses, up to a limit of ED 95 × 3 (0.15 mg/kg). Thereafter, increasing the dose, even up to ED 95 × 8 (0.4 mg/kg), did not appreciably shorten the time to full neuromuscular blockade. The clinical implications of, and pharmacokinetic basis for, these findings are discussed.