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Plasma bupivacaine Concentrations following psoas comprirtment block
Author(s) -
Odoom J. A.,
Zuurmond W. W. A.,
SIH I. L.,
Bovill J.,
Osterlof G.,
Oosting H. V.
Publication year - 1986
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1986.tb13171.x
Subject(s) - bupivacaine , medicine , anesthesia , motor block , plasma concentration , surgery
Summary Fourteen patients undergoing hip replacement surgery under psoas compartment block combined with general anaesthesia were studied. Group 1 (n = 7) received plain and Group 2 (n = 7) received 0.25% bupivacaine with adrenaline. The mean maximirm peak concentrations were 1.93 (SEM 0.46) μg/ml and 1.04 (SEM 0.19) μglmlat 10 minutes in groups I and2 respectively. Bupivacaine concentrations were higher at all times in the group which received plain that the group receiving solution containing adrenaline. These differences were statistically significant at 10, 15 (p< 0.05) and 30 minutes (p < 0.025). The highest recorded plasma bupivacaine concentration was 4.54 μg/ml in one patient receiving plain bupivacaine. No patient developed any signs of toxic svmptoms, the duration of analgesia was longer (p < 0.005) in the group receiving bupivacaine with adrenaline. Bupivataine 0.25% with adrenaline 1:200 000 is safe for psoas compartment block, and is recommended for hip surgery.