Premium
Ketanserin and the cardiovascular system
Author(s) -
GRIFFITHS H. B. A.,
WHITWAM J. G.
Publication year - 1986
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1986.tb12837.x
Subject(s) - medicine , ketanserin , sodium nitroprusside , anesthesia , blood pressure , cardiopulmonary bypass , cardiac index , vascular resistance , placebo , peripheral resistance , heart rate , cardiology , hemodynamics , serotonin , receptor , alternative medicine , pathology , nitric oxide , 5 ht receptor
Summary A double‐blind study was performed on 19 patients undergoing myocardial revascularisation. Routine anaesthetic and cardiopulmonary bypass procedures were used. Nine patients received ketanserin by continuous infusion and ten received an equal infusion rate of placebo. Arterial blood pressure was controlled with sodium nitroprusside. The ketanserin group had a signijicantly higher cardiac index and a lower peripheral vascular resistance during the first 2 hours after bypass.