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Effects of atracurium on intracranial pressure in man
Author(s) -
Unni V.K.N.,
Gray W.J.,
Young H.S.A.
Publication year - 1986
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1986.tb12752.x
Subject(s) - medicine , anesthesia , intracranial pressure , intubation , cerebral perfusion pressure , perfusion , atracurium besilate , muscle relaxation , neuromuscular blockade , cardiology , cerebral blood flow
Summary Intravenous administration of 0.6 mg/kg of atracurium 10 nine patients did not produce any significant change in intracranial, mean arterial or cerebral perfusion pressures. In another three patients, anaesthesia was induced with thiopentone 5 mg/kg after muscle relaxation with atracurium I mg/kg. Intracranial pressure was below pre‐induction levels in two patients whose tracheas were intubated 90 seconds after atracurium. The vocal cords were not fully relaxed at 90 seconds in the third patient. Intubation at 150 seconds in this patient was associated with a rise in intracranial pressure above pre‐induction values.