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Ro 15‐1788 for postoperative recovery
Author(s) -
WOLFF J.,
CARL P.,
CLAUSEN T. G.,
MIKKELSEN B. O.
Publication year - 1986
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1986.tb12741.x
Subject(s) - medicine , midazolam , anesthesia , sedation , placebo , vomiting , nausea , antagonist , surgery , alternative medicine , receptor , pathology
Summary In a double‐blind randomised study, 100 women who underwent induced abortion under midazolam anaesthesia were given the benzodiazepine antagonist Ro 15‐1788 or placebo after termination of anaesthesia. Recovery was assessed by means of a modified Steward coma scale. Following incremental doses of Ro 15‐1788, 56% of the patients were fully awake within 3 minutes and 92% after 5 minutes, which was significant compared to the placebo group. The median duration of amnesia was 91 minutes after Ro 15‐1788 compared to 121 minutes in the placebo group (p<0.001). The median dose of Ro 15‐1788 was 0.4 mg. A slight positive correlation between total dose of Ro 15‐1788 and total amount of midazolam was found. Nausea and/or vomiting were found to be more frequent in the Ro 15‐1788 group, hut otherwise we, found no differences between groups with regard to either side effects or cardiorespiratory function. Ro 15‐1788 is evidently an effective antagonist to the sedation induced by midazolam.