Premium
Comparison of induction characteristics of four intravenous anaesthetic agents
Author(s) -
Mccollum J. S. C.,
Dundee J. W.
Publication year - 1986
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1986.tb12740.x
Subject(s) - medicine , anesthesia , local anaesthetic
Summary The induction characteristics of thiopentone, etomidate and methohexitone have been compared to those of propofol (2,6 di‐isopropyl phenol) in unpremedicated patients. Propofo1 2.5 mg/kg caused significantly more hypotension, excitatory side effects and pain on injection at the dorsum of hand than thiopentone 5 mg/kg. However, with regard to the latter two sequelae. etomidate 0.3 mg/kg and methohexitone 1.5 mg/kg caused similar or more frequent upset. Propofol 2.0 mg/kg was equipotent with thiopentone 4.0 mg/kg in terms of successful induction of anaesthesia. Hypotension may contraindicate the use of propofol in the hypovolaemic or unfit patient.