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Influence of plasma proteins on the onset of hypnotic action of intravenous midazolam
Author(s) -
HALLIDAY N. J.,
DUNDEE J. W.,
COLLIER P. S.,
LOUGHRAN P. G.,
HARPER K. W.
Publication year - 1985
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1985.tb11001.x
Subject(s) - midazolam , medicine , onset of action , pharmacology , hypnotic , in vivo , sedative , pharmacokinetics , aspirin , anesthesia , albumin , drug , plasma concentration , blood proteins , sedation , microbiology and biotechnology , biology
Summary The action of midazolam is influenced by serum protein binding as seen in the relationship between the time of onset of action of a fixed dose of the drug and the plasma albumin. Pretreatment with intravenous aspirin produces a decrease in the in vitro binding of midazolam. In vivo this is manifest as an increase in the rapidity of action of the benzodiazepines. Probenecid pretreatment will also cause a decrease in the onset time of midazolam. However this is not due to altered plasma protein binding of the sedative.