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The estimation of midazolam, a water‐soluble benzodiazepine by gas liquid chromatography
Author(s) -
HOWARD P. J.,
McCLEAN E.,
DUNDEE J. W.
Publication year - 1985
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1985.tb10947.x
Subject(s) - midazolam , chromatography , medicine , benzodiazepine , extraction (chemistry) , reproducibility , gas chromatography , benzene , anesthesia , chemistry , sedation , organic chemistry , receptor
Summary A simple, reliable and reproducible method for the estimation of midazolam in plasma samples is described. This involves extraction with benzene and estimation by gas‐liquid chromatography using diazepam as the internal standard. Reproducibility was good and the extraction from plasma was 94% efjcient.