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Postoperative pain relief with naloxone, Severe respiratory depression and pain after high dose buprenorphine
Author(s) -
Schmidt J.F.,
ChræmmerJørgensen B.,
Pedersen J.E.,
Risbo A.
Publication year - 1985
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1985.tb10903.x
Subject(s) - medicine , buprenorphine , anesthesia , (+) naloxone , analgesic , depression (economics) , respiratory system , pain relief , opioid , surgery , receptor , economics , macroeconomics
Summary Buprenorphine 30 and 40 μg/kg was given as the sole intravenous analgesic in balanced anaesthesia to 12 patients undergoing cholecystectomy. Significant and severe respiratory depression was found 15 minutes after pre‐operative loading with buprenorphine. In the immediate postoperative period six patients were in pain. They were treated with naloxone 0.08–0.4 mg leading to a long lasting period of pain relief (median 22 hours).