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Allergy, plasma IgE level and anaphylactoid response: a hypothesis
Author(s) -
WATKINS J.,
WILD G.,
CLARKE R.S.J.
Publication year - 1985
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1985.tb10790.x
Subject(s) - medicine , immunoglobulin e , atopy , allergy , immunology , anaphylactoid reactions , anaphylaxis , allergic response , antibody , immune system
Summary Any simple test predictive of immediate hypersensitivity‐like (anaphylactoid) response to anaesthetic agents would be clinically useful. Possession of the traits of allergy or atopy, and of raised plasma IgE levels, all easily established, have previously been reported as predisposing factors. The usefulness of such observations has been limited by the fact that many reactions are not immune and do not involve IgE antibodies. This hypothesis suggests how IgE levels may be widely predictive of other reaction mechanisms and partially explains some of the divergent views on the mechanisms of anaphylactoid response which occur in the literature.