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Controlled comparison of nalbuphine and morphine for post‐tonsillectomy pain
Author(s) -
KRISHNAN A.,
TOLHURSTCLEAVER C. L.,
KAY B.
Publication year - 1985
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1985.tb10654.x
Subject(s) - nalbuphine , medicine , tonsillectomy , morphine , anesthesia , placebo , analgesic , intramuscular injection , surgery , opioid , receptor , alternative medicine , pathology
Summary A controlled investigation was conducted to compare the effectiveness of morphine and nalbuphine in the prevention of pain and restlessness after tonsillectomy in children. Sixty children between 4 and 12 years old were randomly allocated to receive intramuscular morphine 0.2 mg/kg, nalbuphine 0.3 mg/kg or no medication approximately 5 minutes before the conclusion of surgery. Pain and restlessness were assessed 1 and 2 hours after injection, and side effects were recorded. The assessments were made double‐blind. Both nalbuphine and morphine decreased restlessness and pain 1 hour (p<0.01) and 2 hours (p<0.05) after surgery. No significant differences were found between the two groups of patients who received opioids. Both nalbuphine and morphine caused more drowsiness than placebo 2 hours after surgery (p < 0.001). Other side effects were uncommon. Nalbuphine may ofSer advantages compared with morphine in regard to safety and convenience of use for the treatment of post‐tonsillectomy pain in children.