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Blocking the circulatory responses to tracheal intubation
Author(s) -
KAY B.,
HEALY T. E. J.,
BOLDER P. M.
Publication year - 1985
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1985.tb10550.x
Subject(s) - medicine , nalbuphine , anesthesia , tracheal intubation , fentanyl , intubation , laryngoscopy , heart rate , saline , tachycardia , blood pressure , hemodynamics , circulatory system , tracheal tube , opioid , cardiology , receptor
Summary The effects of three drug administration programmes on the haemodynamic responses to tracheal intubation have been compared. Thirty patients received thiopentone 4 mg/kg. Ninety seconds later, following the injection of either saline, nalbuphine 0.3 mg/kg or fentanyl 5μg/kg, suxamethonium 1.5 mg/kg was given. The pressor response to tracheal intubation which occurred after saline was reduced after nalbuphine ( p < 0.05) but a tachycardia still occurred. In contrast, neither an increase in blood pressure nor heart rate occurred in those patients given fentanyl. It is concluded that nalbuphine 0.3 mg/kg is only partially efective in reducing the cardiovascular responses to laryngoscopy and tracheal intubation.