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Bupivacaine and prilocaine in intravenous regional anaesthesia
Author(s) -
McKEOWN D. W.,
MEIKLEJOHN B.,
SCOTT D. B.
Publication year - 1984
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1984.tb09504.x
Subject(s) - medicine , bupivacaine , prilocaine , anesthesia , blockade , tourniquet , toxicity , motor block , local anesthetic , surgery , receptor
Summary Six volunteers underwent intravenous regional anaesthesia of the non‐dominant arm on four occasions using two equipotent doses of bupivacaine and prilocaine, administered in a randomised double‐blind sequence. Equipotent doses produced similar degrees of motor and sensory blockade. Bupivacaine produced more rapid motor power loss and delayed motor recovery (p < 0.01). Prilocaine produced more prolonged objective blockade following tourniquet release (p < 0.01), although this was not clinically useful, and bupivacaine led to a marked prolongation of subjective blockade (p < 0.01). Increase of dose with both drugs gave more rapid and complete sensory and motor blockade and delayed recovery (p < 0.05). This was, however, associated with more marked toxicity. It is suggested that in intravenous regional anaesthesia there are no clinical differences between the drugs in equipotent solutions, and that the lower concentrations are the appropriate ones for standard use.