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Nausea and vomiting during spinal anaesthesia
Author(s) -
SPELINA K. R.,
GERBER H. R.,
PAGELS I. L.
Publication year - 1984
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1984.tb09500.x
Subject(s) - metoclopramide , medicine , domperidone , anesthesia , nausea , vomiting , tetracaine , placebo , antiemetic , complication , dose , surgery , dopamine , lidocaine , alternative medicine , pathology
Summary A randomised, double‐blind investigation was undertaken into the value of metoclopramide and domperidone as anti‐emetics in orthopaedic patients who received spinal anaesthesia. Seventy‐seven patients were divided into three statistically comparable groups: Group I received 10 mg metoclopramide, Group II 10 mg domperidone, and Group III NaCl as placebo. These substances were given intravenously before the spinal puncture. There was a comparable decrease in mean arterial blood pressure (MAP), level of sensory block and dose of tetracaine in all three groups. The patients who were nauseated and/or vomited showed a greater decrease in MA P. The incidence of nausea and/or vomiting in the metoclopramide and the placebo group were similar, 20% and 15% respectively, whereas this complication was apparent in 35% of patients who received domperidone. We conclude that metoclopramide and domperidone in the dosages used are ineffective in alleviating nausea and vomiting after spinal anaesthesia.