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Reducing the haemodynamic responses to laryngoscopy and intubation
Author(s) -
BLACK T. E.,
KAY B.,
HEALY T. E. J.
Publication year - 1984
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1984.tb06575.x
Subject(s) - alfentanil , fentanyl , medicine , laryngoscopy , anesthesia , intubation , heart rate , hemodynamics , tracheal intubation , mean arterial pressure , blood pressure , saline , haemodynamic response
Summary The effects of alfentanil and fentanyl on controlling the haemodynamic responses to laryngoscopy and intubation have been compared. Five groups often patients were studied. Induction was with thiopentone 4 mg/kg. Thirty seconds later group 1 received 1 ml/120 kg saline, group 2 received 15μg/kg alfentanil, group 3 received 30 μg/kg alfentanil and group 4 received 5 μg/kg fentanyl. Group 5 received 5 μg/kg fentanyl one minute before induction. Suxamethonium was given 60 seconak after induction and intubation of the trachea was performed 150 seconds after the start of induction. Heart rate and mean arterial pressure were recorded every minute throughout and compared with pre‐induction control values. Control patients (group 1) showed signijicant increases associated with tracheal intubation in all haemodynamic variables. No increases were noted in groups receiving 30 μg/kg alfentanil or 5 μg/kg fentanyl. The heart rate, but not blood pressure, increased with intubation after 15 μg/kg alfentanil. The mean time to movement in 50% of the control patients was 7 minutes. In those given 15 and 30 μg/kg alfentanil it was 11 and 12 minutes respectively. In those given 5 μg/kg fentanyl it was greater than 15 minutes. Alfentanil is shown to reduce the cardiovascular responses to laryngoscopy and intubation and the effect appears to have a shorter duration than that of fentanyl.