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Reversal of neuromuscular block
Author(s) -
HARPER K. W.,
BALI I. M.,
GIBSON F. M.,
CARLISLE R.,
BLACK I. H. C.,
GRAINGER D. J.,
DUNDEE J. W.
Publication year - 1984
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1984.tb06521.x
Subject(s) - neostigmine , atropine , medicine , heart rate , anesthesia , blood pressure
Summary The effect on heart rate of different rates of injection (10 seconds, 1, 3 und 5 minutes) of a fixed dose (neostigmine 2.5 mg and atropine 1.2 mg) and a weight‐related dose (neostigmine 50 μg/kg and atropine 25 μg/kg) of neostigmine‐atropine mixture given for the reversal of residual competitive neuromuscular block was studied in 196 healthy adult patients. In both series slow injection lessened and delayed the initial rise in heart rate. The subsequent fall in heart rate was less when the drugs were injected over 3 min compared with the 10 seconds and 1 minute injection groups but when given over 5 minutes there was a steady fall in heart rate, more so with the weight‐related dose. It is recommended that a neostigmine and atropine mixture should be administered over 3 min.