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Nalbuphine and Althesin anasthesia *
Author(s) -
KAY B.,
HARGREAVES J.,
HEALY T. E. J.
Publication year - 1984
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1984.tb06475.x
Subject(s) - nalbuphine , medicine , anesthesia , saline , general anaesthesia , hyperventilation , surgery , opioid , receptor
Summary In a double‐blind. randomized study of 52 unpremedicated outpatients undergoing cytoscopy, either nalbuphine 20 mg or saline 2 ml was given intravenously immediately before induction of anasthesia with Althesin 0.05 ml/kg. Increments of Althesin 0.5 ml were used to maintain anasthesia. The patients who received nalbuphine required less Althesin than those who received saline (p < 0.001) for a similar duration of surgery, and there was less movement during anasthesia (p < 0.001). During surgery hyperventilation was observed in the patients who received saline; those who received nalbuphine had lower respiratory rates and higher peak expired CO 2 levels (p < 0.001), and also a smaller increase in pulse rate (p < 0.05). Recovery after surgery was faster in the patients who received nalbuphine than those who did not (p < 0.05) and both patients (p < 0.05) and anasthetists (p < 0.001) graded Althesin anasthesia as better after nalbuphine than after saline. Intravenous nalbuphine 20 mg improved Althesin anasthesia for cystoscopy without apparent disadvantages.