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Dose requirements of ICI 35,868 (Propofol, ‘Diprivan’) in a new formulation for induction of anaesthesia
Author(s) -
CUMMINGS G. C.,
DIXON J.,
KAY N. H.,
WINDSOR J. P. W.,
MAJOR E.,
MORGAN M.,
SEAR J. W.,
SPENCE A. A.,
STEPHENSON D. K.
Publication year - 1984
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1984.tb06425.x
Subject(s) - medicine , propofol , anesthesia , incidence (geometry) , adverse effect , pharmacology , physics , optics
Summary In order to avoid Cremophor‐related reactions and reduce the incidence of pain on injection, di‐isopropylphenol (ICI 35,868; propofol) has been reformulated as an emulsion. One hundred and fifteen patients received an induction dose of propofol in the new formulation. The dose required to induce anaesthesia in 95% of healthy, unpremedicated patients was 2.5 mg/kg. Induction was associated with a degree of cardiovascular and respiratory depression. There were no adverse reactions although there were a number of minor side‐effects. The incidence of pain on injection was low (3%) and the overall quality of induction was assessed as good or adequate in 92% of patients.