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Ventilatory response to morphine in young and old subjects
Author(s) -
ARUNASALAM K.,
DAVENPORT H. T.,
PAINTER S.,
JONES J. G.
Publication year - 1983
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1983.tb14062.x
Subject(s) - medicine , morphine , anesthesia , ventilation (architecture) , respiratory minute volume , depression (economics) , tidal volume , respiration , significant difference , age groups , controlled ventilation , respiratory system , mechanical engineering , demography , anatomy , sociology , engineering , economics , macroeconomics
Summary The effects of intravenous morphine (10 mg/70 kg body weight) on ventilation in two groups of subjects, young (age 28–37 years) and old (age 65–82 years) were studied prior to elective surgery. There was no significant difference between the two groups in minute ventilation, ventilatory frequency and end‐tidal carbon dioxide before morphine administration. In both groups there was a significant depression of ventilation and elevation of end tidal carbon dioxide tension 20 minutes after intravenous morphine. There was no significant difference between the two groups in the response of these variables to morphine. However, in the older group seven out of thirteen subjects showed frequent periods of apnoea or periodic breathing whereas three of the young subjects had these phenomena at much less frequent intervals. Respiratory depression after morphine is similar in old and young patienls but old patienls have more change in ventilatory control.