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Intramuscular and oral midazolam. Some factors influencing uptake
Author(s) -
Hildebrand P.J.,
Elwood R.J.,
McClean E.,
Dundee J.W.
Publication year - 1983
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1983.tb12530.x
Subject(s) - midazolam , medicine , metoclopramide , anesthesia , oral administration , intramuscular injection , hyaluronidase , oral dose , incidence (geometry) , pharmacology , sedation , vomiting , biochemistry , chemistry , physics , optics , enzyme
Summary Intramuscular midazolam is better absorbed than when given orally. Addition of hyaluronida.se to the injection significantly increases uptake but causes a high incidence of pain at the injection site. Concurrent administration of oral midazolam and metoclopramide does not increase its uptake.