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The safety of atropine premedication in children with Down's syndrome
Author(s) -
WARK H. J.,
OVERTON J. H.,
MARIAN P.
Publication year - 1983
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1983.tb12253.x
Subject(s) - premedication , atropine , medicine , anesthesia , significant difference
Summary Forty‐five operative procedures were performed in 32 patients with Down's syndrome at the Royal Alexandra Hospital for Children, Sydney in a single year recently. Atropine premedication was administered to 25 patients with Down's syndrome on 38 occasions. Three dosage regimes of atropine were used: 20/μ/kg, 12 μg/kg, both intramuscularly, and 10 μg/kg intravenously. There was no statistically significant difference in the alteration of heart rate for the three dosage groups of atropine used when children with Down's syndrome were compared with weight‐matched control children having similar operative procedures performed.