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Naloxone reversal of meptazinol‐induced respiratory depression
Author(s) -
SLATTERY P. J.,
HARMER M.,
ROSEN M.,
VICKERS M. D.
Publication year - 1982
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1982.tb01780.x
Subject(s) - medicine , (+) naloxone , anesthesia , respiratory system , respiratory rate , depression (economics) , narcotic antagonist , opioid , heart rate , receptor , blood pressure , economics , macroeconomics
Summary The effects of intravenous meptazinol on respiratory rate and end‐tidal CO 2 concentrations were investigated in a group of 20 anaesthetised subjects. In clinically effective doses, meptazinol produced a dose‐related fall in respiratory rate and elevation in end‐tidal CO 2 concentration. Naloxone reversed these effects.