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Acebutolol and coronary artery surgery
Author(s) -
THOMS G. M. M.,
REECE I. J.,
ODOM N. J.,
KAYE C. M.,
SANKEY M. G.
Publication year - 1982
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1982.tb01751.x
Subject(s) - acebutolol , medicine , premedication , regimen , anesthesia , artery , bypass grafting , plasma concentration , coronary artery disease , surgery , propranolol
Summary Plasma levels of acebutolol and its major human metabolite, diacetolol, were determined before, during and after aortocoronary bypass grafting in 10 patients who had received a chronic oral regimen of acebutolol 200 mg t.d.s. for at least 6 days before surgery, a 200 mg dose with the premedication and 5–10 mg intravenously immediately before intubation. It was found that this regimen produced beta‐adrenoceplor antagonist levels which were within the range in which attenuation of hypertension and tachydysrhythmiu occurs. These effective plasma levels were sustained throughout surgery and persisted into the early recovery period.