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Diazepam and suxamethonium muscle pain (a dose‐response study)
Author(s) -
Verma R.S.
Publication year - 1982
Publication title -
anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.839
H-Index - 117
eISSN - 1365-2044
pISSN - 0003-2409
DOI - 10.1111/j.1365-2044.1982.tb01284.x
Subject(s) - diazepam , fasciculation , medicine , anesthesia , incidence (geometry) , muscle spasm , muscle relaxant , significant difference , optics , physics
Summary Postoperative muscle pain occurred in 17.2% of patients given diazepam intravenously 5 minutes prior to suxamethonium. The incidence of muscle pain was 48% in those patients who were not given diazepam before suxamethonium. The difference is statistically significant (p < 0.01). Five mg diazepam reduced the incidence of pain but not significantly (p = 0.30); 10 mg diazepam significantly reduced the incidence (p < 0.05); while 15 and 20 mg diazepam showed belter effects (p < 0.01). Diazepam pretreatment also reduced the severity, frequency and duration of muscle pain. The incidence of fasciculations was significantly reduced hut there was no correlation between the incidence of fasciculations and the occurrence of muscle pains.